| 货号 | 4889/50 |
| 别名 | 2-[2-(3-Chloro-4-methoxyphenyl)ethy |
| 供应商 | Tocris |
| 生物活性 | Potent CBP/p300 bromodomain (BRD) inhibitor (Kd values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 509.04 |
| 分子式 | C28H33ClN4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Gallenkampet al (2014) Bromodomains and their pharmacological inhibitors. ChemMedChem 9 438. PMID: 24497428. Hayet al (2014) Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J.Am.Chem.Soc. 136 9308. PMID: 24946055. |