| 货号 | 2608/50 |
| 别名 | 4-[[(1R)-2-[[(2R)-3-(1H-Indol-3-yl) |
| 供应商 | Tocris |
| 生物活性 | Potent and selective, nonpeptide CCK2 receptor antagonist (IC50 values are 2.8 and 1232 nM for CCK2 and CCK1 respectively) that displays negligible affinity at GABAA, benzodiazepine, substance P, neurotensin, opioid, bradykinin and 5-HT3 receptors (IC50 > 10 μM). Exhibits anxiolytic activity in elevated plus maze and social interaction tests and increases food intake in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 616.76 |
| 分子式 | C35H44N4O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 130325-35-8 |
| 参考文献 | Tsutsumiet al (1999) Suppression of conditioned fear by administration of CCKB receptor antagonist PD135158. Neuropeptides 33 483. PMID: 10657528. Dorre and Smith (1998) CholecystokininB receptor antagonist increases food intake in rats. Physiol.Behav. 65 11. PMID: 9811359. Hugheset al (1990) Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc.Natl.Acad.Sci.USA 876728. |