I-CBP 112 (50 MG)
货号：
4891/50 基本售价：
15545.9 元 规格：
50 mg
产品信息
概述| 货号 | 4891/50 |
| 别名 | 1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one |
性能| 供应商 | Tocris |
| 生物活性 | CBP/p300 bromodomain inhibitor (IC50 values are 0.142-0.17 and 0.625 μM for CBP and p300 respectively). Selective for CBP and p300 over ATAD2, BAZ2B, BRD2(2), BRD4(1), PB1(5), PCAF, PHIP(2) and TIF1α bromodomains in a BLI assay. Accelerates FRAP recovery in cells at a concentration of 1 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 468.59 |
| 分子式 | C27H36N2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl |
| 参考文献 | Gallenkampet al (2014) Bromodomains and their pharmacological inhibitors. ChemMedChem 9 438. PMID: 24497428. |
