| 货号 | 5051/50 |
| 别名 | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophen |
| 供应商 | Tocris |
| 生物活性 | Highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1,α9β1,α2β1,α4β7andαIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 817.78 |
| 分子式 | C38H46Cl2N6< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH |
| 参考文献 | Ramirezet al (2009) BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 1340 1340. PMID: 19571319. Xuet al (2008) A chemical approach to stem-cell biology and regenerative medicine. Nature 453 338. PMID: 18480815. Leoneet al (2003) An assessment of the mechanistic differences between two integrin α4β1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 305 1150. PMID: 12626659. |