| 货号 | 4839/50 |
| 别名 | (-)-2-[[(1R)-1-[7-Methyl-2-(4-morph |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 408.45 |
| 分子式 | C22H24N4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl |
| 参考文献 | Niet al (2012) Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2 425. PMID: 22588880. Nylanderet al (2012) Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 10 2127. PMID: 22906130. |