AZ 20 (50 MG)
货号：
5198/50 基本售价：
15545.9 元 规格：
50 mg
产品信息
概述| 货号 | 5198/50 |
| 别名 | 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective ATR kinase inhibitor (IC50 = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 412.51 |
| 分子式 | C21H24N4O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 10 mM in ethanol |
| 参考文献 | Footeet al (2013) Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J.Med.Chem. 56 2125. PMID: 23394205. |
