| 货号 | 4927/50 |
| 别名 | N-[(1S)-2-Hydroxy-1-phenylethyl]-N'- |
| 供应商 | Tocris |
| 生物活性 | Potent, ATP-competitive ROCK inhibitor (IC50 values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC-α and PRKX (IC50 values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 333.38 |
| 分子式 | C20H19N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Liet al (2012) Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. J.Med.Chem. 55 2474. PMID: 22272748. Yoshimiet al (2010) Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J.Pharmacol.Exp.Ther. 334 955. PMID: 20534789. |