Adapalene
货号：
13655-1g 基本售价：
15456.0 元 规格：
1 g
产品信息
概述| 货号 | 13655-1g |
| 描述 | Adapalene, a synthetic naphthoic acid derivative, is a selective agonist of retinoic acid receptor (RAR)-β and RAR-γ (Kds = 34 and 130 nM, respectively).1 At 0.1-10 µM, adapalene dose-dependently inhibits sebocyte growth, proliferation, and differentiation in a primary rat preputial cell culture system.1 Adapalene demonstrates anti-inflammatory and immunomodulatory activity by inhibiting 5-lipoxygenase-catalyzed leukotriene production and expression of toll-like receptor 2 on human monocytes.2 It is commonly used for the study of the pathogenesis and treatment of acne vulgaris.3 |
| 别名 | CD 271;Differin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, M.J.,Ciletti, N.,Michel, S., et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. Journal of Investigative Dermatology 114, 349-353 (2000).
2.Jones, D.A. The potential immunomodulatory effects of topical retinoids. Dermatology Online Journal 11(1), 3 (2005).
3.Thiboutot, D. New treatments and therapeutic strategies for acne. Archives of Family Medicine 9, 179-187 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 412.5 |
| 分子式 | C28H28O3 |
| CAS号 | 106685-40-9 |
| 稳定性 | ≥ 2 years |
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