| 货号 | 4247/50 |
| 别名 | 1-[4-[4-(1-Oxopropyl)-1-piperazinyl |
| 供应商 | Tocris |
| 生物活性 | Potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. Induces autophagy in HeLa cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 607.62 |
| 分子式 | C35H28F3N5 |
| 可溶性/溶解性 | Soluble to 1 mM in DMSO with gentle warming |
| 参考文献 | Petersonet al (2011) mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 146 408. PMID: 21816276. Liuet al (2010) Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J.Med.Chem. 53 7146. PMID: 20860370. Guertin and Sabatini (2009) The pharmacology of mTOR inhibition. Sci.Signal. 2 pe24. PMID: 19383975. Thoreenet al (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J.Biol.Chem. 284 8023. PMID: 19150980. |