Toceranib (50 MG)
货号：
3909/50 基本售价：
15248.5 元 规格：
50 mg
产品信息
概述| 货号 | 3909/50 |
| 别名 | 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide; Palladia |
性能| 供应商 | Tocris |
| 生物活性 | Potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 396.46 |
| 分子式 | C22H25FN4O2< |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| 参考文献 | Liaoet al (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 100 585. PMID: 12091352. |
