| 货号 | 4101/50 |
| 别名 | (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dim |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μMin vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 568.09 |
| 分子式 | C28H30ClN5O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Seiwertet al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69 3021. PMID: 19318576. Sattleret al (2003) A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 63 5462. PMID: 14500382. Wanget al (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth. Mol.Cancer Ther. 2 1085. PMID: 14617781. |