| 货号 | 89460-10mg |
| 描述 | Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 µM.1 Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 µM),2, inhibition of Grb2-Shc interaction (IC50 = 22 µM),3, and antagonism of endothelin receptors (IC50 = 114 and 152 µM for human ETA and ETB, respectively).4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chidananda, C. and Sattur, A.P. Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans. Journal of Agricultural and Food Chemistry 55, 2879-2883 (2007). 2.Tomoda, H.,Matsushima, C.,Tabata, N., et al. Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones. Journal of Antibiotics 52(2), 160-170 (1999). 3.Ji-Youn, N.,Son, K.H.,Kim, H.K., et al. Sclerotiorin and isochromophilone IV: Inhibitors of Grb2-Shc interaction, isolated from Penicillium multicolor F1753. Journal of Microbiology and Biotechnology 10(4), 544-546 (2000). 4.Pairet, L.,Wrigley, S.K.,Chetland, I., et al. Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: Taxonomy, fermentation, isolation, structure elucidation and biological activity. Journal of Antibiotics 48(9), 913-923 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.9 |
| 分子式 | C21H23ClO5 |
| CAS号 | 549-23-5 |
| 稳定性 | ≥ 2 years |
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