| 货号 | 15966-10mg |
| 描述 | Prostaglandin E2(PGE2; Item No. 14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.1,2,3 CAY10684 is a lactam that acts as a potent EP4 agonist, triggering cAMP signaling with an EC50 value of 0.8 nM.4 It displays more than 1,000-fold selectivity for EP4 over other EP receptors.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, M.,Thompson, D.D. and Paralkar, V.M. Prostaglandin E2 receptors in bone formation. International Orthopaedics 31, 767-772 (2007). 2.Hawcroft, G.,Ko, C.W.S. and Hull, M.A. Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. Oncogene 26, 3006-3019 (2007). 3.Babaev, V.R.,Chew, J.D.,Ding, L., et al. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metabolism 8, 492-501 (2008). 4.Elworthy, T.R.,Kertesz, D.J.,Kim, W., et al. Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-sterochemical and lower side-chain optimization. Bioorganic & Medicinal Chemistry Letters 14, 1655-1659 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470 |
| 分子式 | C27H32ClNO4 |
| CAS号 | 493035-81-7 |
| 稳定性 | ≥ 1 year |
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