Licofelone
货号：
10007692-50mg 基本售价：
15050.0 元 规格：
50 mg
产品信息
概述| 货号 | 10007692-50mg |
| 描述 | Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression.1 The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively.2 Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.3 |
| 别名 | ML 3000; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Marcouiller, P.,Pelletier, J.P.,Guévremont, M., et al. Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: Regulating factors for interleukin 1β synthesis. Journal of Rheumatology 32(4), 704-712 (2005).
2.Laufer, S.A.,Augustin, J.,Dannhardt, G., et al. (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. Journal of Medicinal Chemistry 37, 1894-1897 (1994).
3.Smolka, A.J.,Goldenring, J.R.,Gupta, S., et al. Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC Gastroenterol. 4(4), 1-11 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.9 |
| 分子式 | C23H22ClNO2 |
| CAS号 | 156897-06-2 |
| 稳定性 | ≥ 2 years |
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