HPF
货号：
10159-5mg 基本售价：
15008.0 元 规格：
5 mg
产品信息
概述| 货号 | 10159-5mg |
| 描述 | The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.1 There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2).2 HPF is a cell-permeable aromatic amino-fluorescein derivative that has little intrinsic fluorescence. It undergoes oxidation only by highly reactive oxygen species (hROS) such as the hydroxyl radical, peroxynitrite, and hROS generated from a peroxidase/H2O2 system. It is inert to hypochlorite ion, nitric oxide, hydrogen peroxide (H2O2), superoxide, and other oxidants. Upon oxidation, HPF is converted to the highly fluorescent molecule fluorescein, allowing the simple direct detection of highly reactive biological radicals.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Matés, J.M.,Pèrez-Gómez, C. and Nuñez de Castro, I. Antioxidant enzymes and human diseases. Clinical Biochemistry 32(8), 595-603 (1999).
2.Hempel, S.L.,Buettner, G.R.,OMalley, Y.Q., et al. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2,7-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2,7-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radical Biology & Medicine 27(1), 146-159 (1999).
3.Setsukinai, K.i.,Urano, Y.,Kakinuma, K., et al. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. The Journal of Biological Chemisty 278(5), 3170-3175 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 424.4 |
| 分子式 | C26H16O6 |
| CAS号 | 359010-69-8 |
| 稳定性 | ≥ 1 year |
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