| 货号 | 62570-25mg |
| 描述 | Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase. Like many products of sphingomyelin, it exhibits a wide range of biological activities. Not only does it enhance cell growth,1 but it can inhibit the normal apoptotic response to a variety of stimuli.2 The ability of PKC to block apoptosis is likely due to the formation of S1P. S1P stimulates MAPK and counteracts the ceramide-induced activation of SAPK and JNK.2 It also increases intracellular calcium levels by both the liberation of calcium from internal stores3 and through activation of a Gi protein-coupled receptor resulting in the opening of a cell surface calcium channel.4 |
| 别名 | S1P;Sphingosine-1-Phosphoric Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Olivera, A., and Spiegel, S. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365, 557-560 (1993). 2.Cuvillier, O.,Pirianov, G.,Kleuser, B., et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381, 800-803 (1996). 3.Mattie, M.,Brooker, G., and Spiegel, S. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. The Journal of Biological Chemisty 269, 3181-3188 (1994). 4.van Koppen, C.J.,zu Heringdorf, D.M.,Laser, K.T., et al. Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. The Journal of Biological Chemisty 271, 2082-2087 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.5 |
| 分子式 | C18H38NO5P |
| CAS号 | 26993-30-6 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |