| 货号 | 13624-25g |
| 描述 | The cyclic nucleotide second messenger guanosine 3’5’-cyclic monophosphate (cGMP) is an important mediator of signal transduction and hence a wide range of cellular processes. It is generated by soluble- and particulate-type guanylyl cyclase and degraded via members of the phosphodiesterase (PDE) protein family. Icariin, the active component of the Chinese medicinal plant E. brevicornum, is an inhibitor of human recombinant PDE5 with an IC50 value of 5.9 µM.1 It is a prenylated flavonol that has been used to treat erectile dysfunction and has been shown to have anti-cancer and antioxidant activity.2 At a concentration of 1 x 107 mol/L, icariin induces differentiation of cardiomyocytes and upregulates the expression of cardiac genes.3 At 20 µg/ml, icariin increases the proliferation and differentiation of cultured human osteoblasts, which appears to be mediated in part by upregulating bone morphogenetic protein 2 mRNA.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.DellAgli, M.,Galli, G.V.,Dal Cero, E., et al. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. Journal of Natural Products 71(9), 1513-1517 (2008). 2.Chen, Y.,Zhao, Y.H.,Jia, X.B., et al. Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed epimedium koreanum Nakai (Yin Yanghuo). Pharmaceutical Research 25(9), 2190-2199 (2008). 3.Ding, L.,Liang, X.g.,Zhu, D.y., et al. Icariin promotes expression of PGC-1α, PPARα, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacologica Sinica 28(10), 1541-1549 (2007). 4.Yin, X.x.,Chen, Z.q.,Liu, Z.j., et al. Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2. Chinese Medical Journal 120(3), 204-210 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 676.6 |
| 分子式 | C33H40O15 |
| CAS号 | 489-32-7 |
| 稳定性 | ≥ 2 years |
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