| 货号 | 5148/50 |
| 别名 | 4-(2-Methyl-4-pyridinyl)-N-[4-(3-py |
| 供应商 | Tocris |
| 生物活性 | Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 379.45 |
| 分子式 | C25H21N3O |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Burridgeet al (2014) Chemically defined generation of human cardiomyocytes. Nat.Methods 11 855. PMID: 24930130. Proffittet al (2013) Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 73 502. PMID: 23188502. Wendet al (2013) WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol.Med. 5 264. PMID: 23307470. Youssefet al (2012) Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat. Cell Biol. 14 1282. PMID: 23178882. |