UNC 0642 (50 MG)
货号：
5132/50 基本售价：
14951.1 元 规格：
50 mg
产品信息
概述| 货号 | 5132/50 |
| 别名 | 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM). Exhibits >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases. Reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 546.7 |
| 分子式 | C29H44F2N6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| 参考文献 | Liuet al (2013) Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J.Med.Chem. 56 8931. PMID: 24102134. |
