| 货号 | 4840/50 |
| 别名 | 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-o |
| 供应商 | Tocris |
| 生物活性 | Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kδ, PI 3-Kβ, PI 3-Kα and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ~2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%; maximumeffect seen at 250 nM. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 582.71 |
| 分子式 | C33H34N4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in 2eq.HCl |
| 参考文献 | Robertet al (2015) Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 7 93. PMID: 26307031. Muncket al (2012) Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Mol.Cancer Ther. 11 1789. PMID: 22576130. Dumontet al (2009) Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin.Ther.Patents 19 775. PMID: 19456277. |