| 货号 | 5408/50 |
| 别名 | N-(3-Aminopropyl)-N-[(1R)-1-[7-chlo |
| 供应商 | Tocris |
| 生物活性 | High affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 517.06 |
| 分子式 | C30H33ClN4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Purcellet al (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin.Cancer Res. 16 566. PMID: 20068098. Ladet al (2008) Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47 3576. PMID: 18290633. Daviset al (2006) Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer 6 22. PMID: 16433906. |