| 货号 | 4668/50 |
| 别名 | 4-(4-,9-Diethoxy-1,3-dihydro-1-oxo- |
| 供应商 | Tocris |
| 生物活性 | Selective prostanoid EP4 receptor competitive antagonist with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays). Affinity for all other prostanoid receptors is < 5.3. Inhibits U-46619 induced human platelet aggregation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 544.62 |
| 分子式 | C30H28N2O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Wilsonet al (2006) GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br.J.Pharmacol. 148 326. PMID: 16604093. Jones and Chanet al (2005) Investigation of the agonist activity of prostacyclin analogues on prostanoid EP4 receptors using GW 627368 and taprostene: evidence for species differences. Prostaglandins Leukot.Essent.Fatty.Acids. 72 289. PMID: 15763441. |