| 货号 | 4291/50 |
| 别名 | 6-Bromo-7-[4-[(5-methyl-3-isoxazoly |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 μM at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a range of human tumor cell lines. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 551.48 |
| 分子式 | C26H31BrN8O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Faisalet al (2011) The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol.Cancer Ther. 10 2115. PMID: 21885865. Bavetsiaset al (2010) Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J.Med.Chem. 53 5213. PMID: 20565112. |