| 货号 | 4753/50 |
| 别名 | N-Cyclopropyl-3-[3-(1,1-dimethyleth |
| 供应商 | Tocris |
| 生物活性 | Potent and selective p38α inhibitor (IC50 = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 402.41 |
| 分子式 | C21H21F3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Aiguadéet al (2012) Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. Bioorg.Med.Chem.Lett. 22 3431. PMID: 22521646. Balaguéet al (2012) Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br.J.Pharmacol. 166 1320. PMID: 22229697. |