| 货号 | 501020-480Well |
| 描述 | Thromboxane A2(TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle.1,2,3 Like most lipid mediators, TXA2 is not a circulating hormone. It is formed in response to local stimuli and exerts its effects within a short distance of its biosynthesis. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2, which is then quickly metabolized (t½ = 5-7 minutes) to urinary metabolites for clearance by the kidneys.4 Because of the transient nature of this compound it is difficult to accurately measure circulating levels in whole animal experimental models. In fact, it has been shown that plasma and urine levels of TXB2 are primarily due to ex vivo platelet activation and intra-renal production, respectively.4,5,6 Therefore, measurement of TXB2 metabolites, such as 11-dehydro TXB2 (Item No. 519510), in urine and plasma may give more accurate estimates of in vivoTXA2production.7,8,9TXB2 measurement is better suited for samples that are unlikely to undergo extensive metabolism such as perfusates, lavage samples, tissue/cell culture, etc. |
| 别名 | TXB2 EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hamberg, M.,Svensson, J. and Samuelsson, B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proceedings of the National Academy of Sciences of the United States of America 72, 2994-2998 (1975). 2.Ellis, E.F.,Oelz, O.,Roberts, L.J., II, et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193, 1135-1137 (1976). 3.Salzman, P.M.,Salmon, J.A. and Moncada, S. Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery. Journal of Pharmacology and Experimental Therapeutics 215, 240-247 (1980). 4.Patrono, C.,Ciabattoni, G.,Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. Journal of Clinical Investigation 77, 590-594 (1986). 5.Patrono, C.,Ciabattoni, G.,Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 11, 493-498 (1983). 6.Samuelsson, B.,Granström, E.,Green, K., et al. Prostaglandins. Annual Reviews of Biochemistry 44, 669-695 (1975). 7.Catella, F.,Healy, D.,Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proceedings of the National Academy of Sciences of the United States of America 83, 5861-5865 (1986). 8.Ciabattoni, G.,Pugliese, F.,Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochimica et Biophysica Acta 992, 66-70 (1989). 9.Murphy, R.C. and Fitzgerald, G.A. Current approaches to estimation of eicosanoid formation in vivo. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 22, 341-348 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |