Ophiobolin C
货号：
20186-5mg 基本售价：
14812.0 元 规格：
5 mg
产品信息
概述| 货号 | 20186-5mg |
| 描述 | Ophiobolin C is a sesterterpenoid fungal phytoxin produced by many species of the genus Bipolaris. It has been identified as an antagonist of chemokine receptor CCR5 binding (IC50 = 40 µM) to the envelop protein gp120 and to CD4, which is known to mediate HIV-1 viral entry into cells.1 Ophiobolin C is also reported to be cytotoxic to chronic lymphocytic leukemia cells (LC50 = 8 nM).2 |
| 别名 | Zizanin A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jayasurla, H.,Herath, K.B.,Ondeyka, J.G., et al. Isolation and structure of antagonists of chemokine receptor (CCR5). J.Nat.Prod 67(6), 1036-1038 (2004).
2.Bladt, T.T.,Dürr, C.,Knudsen, P.B., et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules 18(12), 14629-14650 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 386.6 |
| 分子式 | C25H38O3 |
| CAS号 | 19022-51-6 |
| 稳定性 | ≥ 2 years |
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