Microcystin-LA
货号：
10007187-500ug 基本售价：
14700.0 元 规格：
500 ug
产品信息
概述| 货号 | 10007187-500ug |
| 描述 | Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.1 They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A.2 Microcystin-LA differs from the major microcystin variant LR (Item No. 10007188) with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.3 |
| 别名 | Cyanoginosin-LA;Toxin BE4 (Microcystis aeruginosa); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rinehart, K.L.,Harada, K.i.,Namikoshi, M., et al. Nodularin, microcystin, and the configuration of Adda. Journal of the American Chemical Society 110, 8557-8558 (1988).
2.Ito, E.,Takai, A.,Kondo, F., et al. Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon 40, 1017-1025 (2002).
3.Aggen, J.B.,Humphrey, J.M.,Gauss, C.M., et al. The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: rational modifications imparting PP1 selectivity. Bioorganic & Medicinal Chemistry 7(3), 543-564 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 910.1 |
| 分子式 | C46H67N7O12 |
| CAS号 | 96180-79-9 |
| 稳定性 | ≥ 1 year |
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