| 货号 | 2681/50 |
| 别名 | 17-Phenyl-(3α,5α)-androst-16-en-3-ol |
| 供应商 | Tocris |
| 生物活性 | Selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors. Selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 350.54 |
| 分子式 | C25H34O |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 694438-95-4 |
| 参考文献 | Akket al (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor. Mol.Pharmacol. 71 461. PMID: 17105870. Kelleyet al (2007) Antagonism of neurosteroid modulaton of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol. Eur.J.Pharmacol. 572 94. PMID: 17658511. Mennericket al (2004) Selective antagonism of 5α-reduced neurosteroid effects at GABAA receptors. Mol.Pharmacol. 65 1191. PMID: 15102947. |