| 货号 | 1208/50 |
| 别名 | (2R,4R)-4-Aminopyrrolidine-2,4-dica |
| 供应商 | Tocris |
| 生物活性 | A highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo. Also available as part of the Group II mGlu Receptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 174.16 |
| 分子式 | C6H10N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 169209-63-6 |
| 参考文献 | Schoeppet al (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38 1431. PMID: 10530808. Monnet al (1996) Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. J.Med.Chem. 39 2990. PMID: 8709133. Schoeppet al (1995) Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate. Neuropharmacology 34 843. PMID: 8532165. |