XL 388 (50 MG)
货号：
4893/50 基本售价：
14356.2 元 规格：
50 mg
产品信息
概述| 货号 | 4893/50 |
| 别名 | [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective mTOR inhibitor (IC50 = 9.9 nM). Inhibits mTOR activity in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 455.5 |
| 分子式 | C23H22FN3O4< |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Takeuchiet al (2013) Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J.Med.Chem. 56 2218. PMID: 23394126. |
