| 货号 | 4038/50 |
| 别名 | N-[4-[[2-(1,1-Dimethylethyl)phenyl] |
| 供应商 | Tocris |
| 生物活性 | Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 573.7 |
| 分子式 | C33H35NO6S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 877877-35-5 |
| 参考文献 | Ashimoriet al (2009) TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Mol.Cancer.Ther. 8 893. PMID: 19372562. Wanget al (2009) TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 69 2757. PMID: 19318573. Wanget al (2006) Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J.Med.Chem. 49 6139. PMID: 17034116. Zeitlinet al (2006) Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. Cancer Res. 66 8698. PMID: 16951185. |