PF 5274857 hydrochloride (50 MG)
货号：
5262/50 基本售价：
14356.2 元 规格：
50 mg
产品信息
概述| 货号 | 5262/50 |
| 别名 | 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | High affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 473.42 |
| 分子式 | C20H25ClN4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Rohneret al (2011) Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier. Mol.Cancer Ther. 11 57. PMID: 22084163. |
