| 货号 | 4237/50 |
| 别名 | 2-[(2-Chloro-4-iodophenyl)amino]-N- |
| 供应商 | Tocris |
| 生物活性 | Selective MEK inhibitor (Ki = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 478.66 |
| 分子式 | C17H14ClF2IN |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Solitet al (2006) BRAF mutation predicts sensitivity to MEK inhibition. Nature 439 358. PMID: 16273091. McDaidet al (2005) Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. Cancer Res. 65 2854. PMID: 15805287. Allenet al (2003) CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK). Semin.Oncol. 30 105. PMID: 14613031. |