| 货号 | 1677/50 |
| 别名 | 2-[[4-[2-[[(Cyclohexylamino)carbony |
| 供应商 | Tocris |
| 生物活性 | Potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro. Has lipid-lowering effects following oral administration in vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 502.75 |
| 分子式 | C29H46N2O3S |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 265129-71-3 |
| 参考文献 | Paukkeriet al (2007) PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. Br.J.Pharmacol. 152 1081. PMID: 17891158. Cunardet al (2002) Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J.Immunol. 168 2795. PMID: 11884448. Muoioet al (2002) Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes 51 901. PMID: 11916905. Brownet al (2001) Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg.Med.Chem.Lett. 11 1225. PMID: 11354382. |