| 货号 | 3823/50 |
| 别名 | 4-[5-[8-(1-Methylethyl)-4-phenyl-2- |
| 供应商 | Tocris |
| 生物活性 | Antagonist of RARα receptors (IC50 = 31.2 nM). Displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβrespectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 432.51 |
| 分子式 | C29H24N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Somenziet al (2007) Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. PLoS ONE 9 e836. PMID: 17786207. Renet al (2005) Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance. Mol.Cell.Biol. 25 10591. PMID: 16287870. Kikuchiet al (2001) Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists. Bioorg.Med.Chem.Lett. 11 1215. PMID: 11354380. |