| 货号 | 4140/50 |
| 别名 | 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 610.45 |
| 分子式 | C24H27N9O6 |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 50 mM in DMSO |
| 参考文献 | Ferrariset al (2010) Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J.Med.Chem. 53 4561. PMID: 20364863. Gaymeset al (2009) Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 94 638. PMID: 19407318. Jagtapet al (2004) The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). Bioorg.Med.Chem.Lett. 14 81. PMID: 14684303. |