| 货号 | 1673/50 |
| 别名 | (RS)-2-Amino-3-(4-chloro-3-hydroxy- |
| 供应商 | Tocris |
| 生物活性 | Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 206.59 |
| 分子式 | C6H7ClN2O4 |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| 参考文献 | Bjerrumet al (2003) Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J.Med.Chem. 46 2246. PMID: 12747796. Kristensenet al (2002) Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist. Soc.Neurosci.Abstr. 540.7. |