| 货号 | 3242/50 |
| 别名 | 1,4-Dihydro-4-[3-[[[[3-[4-(3-methox |
| 供应商 | Tocris |
| 生物活性 | Potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1,α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 680.79 |
| 分子式 | C33H42N4O6.C3H6O3 |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in DMSO |
| CAS号 | 186185-03-5 |
| 参考文献 | Antal-Zimanyiet al (2008) Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist Eur.J.Pharmacol. 590 224. PMID: 18573246. Poindexteret al (2004) Dihydropyridine neuropeptide Y Y1 receptor antagonists 2: bioisosteric urea replacements Bioorg.Med.Chem. 12 507. PMID: 14723969. Poindexteret al (2002) Dihydropyridine neuropeptide Y Y1 receptor antagonists. Bioorg.Med.Chem.Letts. 12379. |