| 货号 | 3963/50 |
| 别名 | N-(2-Chloro-5-methoxyphenyl)-6-meth |
| 供应商 | Tocris |
| 生物活性 | Src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitroandin vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 442.94 |
| 分子式 | C23H27ClN4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Summyet al (2005) AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol.Cancer Ther. 4 1900. PMID: 16373705. Yezhelyevet al (2004) Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin.Cancer Res. 10 8028. PMID: 15585638. |