AC 710 (50 MG)
货号：
5013/50 基本售价：
14356.2 元 规格：
50 mg
产品信息
概述| 货号 | 5013/50 |
| 别名 | N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 562.7 |
| 分子式 | C31H42N6O4 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Liuet al (2012) Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 3 997. PMID: 24900421. |
