| 货号 | 5097/50 |
| 别名 | 4a,7a-Dihydro-2-(1-hydroxyundecyl)- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 534.65 |
| 分子式 | C30H38N4O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Schellenberget al (2011) DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 108 20855. PMID: 22184240. Freschaufet al (2010) Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 285 2351. PMID: 19940137. Freschaufet al (2009) Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 69 7739. PMID: 19773431. |