| 货号 | 4487/50 |
| 别名 | N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydr |
| 供应商 | Tocris |
| 生物活性 | Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro(IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 603.59 |
| 分子式 | C32H28F3N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Cambienet al (2009) Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br.J.Cancer 100 1755. PMID: 19436305. Johnsonet al (2007) Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg.Med.Chem.Lett. 17 3339. PMID: 17448658. Walseret al (2006) Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res. 66 7701. PMID: 16885372. |