| 货号 | 534721-480Well |
| 描述 | 15(S)-HETE is produced from arachidonic acid by the enzyme 15-lipoxygenase (15-LO). In humans it is formed primarily in the respiratory epithelium, leukocytes, and reticulocytes.1 15(S)-HETE has been detected in high concentrations in nasal secretions and may contribute to allergic rhinitis.2 15(S)-HETE has anti-inflammatory properties, inhibiting carragheenan-induced arthritis and lowering leukotriene B4(LTB4) concentrations in the synovial fluid of dogs.3 It may regulate T-lymphocytes by inhibiting 5- and 12-LOs.4 It is also a vasoconstrictor, constricting cerebral and coronary arteries of dogs in vitro and cerebral arteries of pigs in vivo.5 15(S)-HETE may also play a role in cancer, inhibiting apoptosis by carcinosarcoma cells.6 Our 15(S)-HETE ELISA is a competitive assay that permits the measurement of 15(S)-HETE within the range of 39-5,000 pg/ml, typically with a sensitivity (80% B/B0) of 170 pg/ml. This assay is very specific for 15(S)-HETE, showing very low crossreactivity to other HETEs. |
| 别名 | 15(S)-HETE EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hunter, J.A.,Finkbeiner, W.E.,Nadel, J.A., et al. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proceedings of the National Academy of Sciences of the United States of America 82, 4633-4637 (1985). 2.Ramis, I.,Roselló-Catafau, J.,Bulbena, O., et al. 15-Hydroxyeicosatetraenoic acid as a major eicosanoid in nasal secretions: Assay by high-performance liquid chromatographic-radioimmunoassay and gas chromatographic-mass spectrometric procedures. Journal of Chromatography 496, 416-422 (1989). 3.Fogh, K.,Stender Hansen, E.,Herlin, T., et al. 15-Hydroxy-eicosatetraenoic acid, (15-HETE) inhibits carragheenan-induced experimental arthritis and reduces synovial fluid leukotriene B4(LTB4). Prostaglandins 37, 213-228 (1989). 4.Bailey, J.M.,Bryant, R.W.,Low, C.E., et al. Regulation of T-lymphocyte mitogenesis by the leukocyte product 15-hydroxy-eicosatetraenoic acid (15-HETE). Cellular Immunology 67, 112-120 (1982). 5.Lovelady, G.K.,Mirro, R.,Armstead, W.M., et al. Effect of 15-HETE on cerebral arterioles of newborn pigs. Prostaglandins 36, 507-513 (1988). 6.Tang, D.G.,Chen, Y.Q. and Honn, K.V. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proceedings of the National Academy of Sciences of the United States of America 93, 5241-5246 (1996). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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