| 货号 | 516671-480Solid |
| 描述 | Prostaglandin F2α(PGF2α) is one of the five primary prostaglandins derived enzymatically directly from the endoperoxide PGH2. PGF2α was initially discovered in seminal fluid, and to date the majority of the functional roles ascribed to it relate to fertility, pregnancy, and parturition. PGF2α is a potent luteolytic agent and is used to induce ovulation in domestic livestock. It is also a potent uterine stimulant, and is part of the cascade of myometrial stimulants which induce and sustain labor. PGF2α is rapidly metabolized to 13,14-dihydro-15-keto PGF2αin vivo, by the enzymes 15-hydroxy prostaglandin dehydrogenase and Δ13-reductucase.1,2,3,4 Measurement of 13,14-dihydro-15-keto PGF2α in plasma can be used as a marker of the in vivo production of PGF2α.5,6 The Cayman Chemical 13,14-dihydro-15-keto PGF2α Enzyme Immunoassay is a competitive assay that provides measurements of 13,14-dihydro-15-keto PGF2α within the range of 2.3-5,000 pg/ml, typically with a detection limit (80% B/B0) of approximately 15 pg/ml. Although the tracer and antiserum for this assay have been sold separately for many years, the reagents are now combined with an accurate standard and packaged together in a convenient assay kit. The assay has been validated for the measurement of 13,14-dihydro-15-keto PGF2α in plasma, a common matrix for measurement of this PGF2αmetabolite.5 |
| 别名 | 13,14-dihydro-15-keto PGF2α EIA Kit;PGFM EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Samuelsson, B.,Granström, E.,Green, K., et al. Prostaglandins. Annual Reviews of Biochemistry 44, 669-695 (1975). 2.Keirse, M.J.N.C. and Turnbull, A.C. Metabolism of prostaglandins within the pregnant uterus. British Journal of Obstetrics and Gynaecology 82, 887-893 (1975). 3.Basu, S. and Stjernschantz, J. Δ13-reductase dependent metabolism of prostaglandins in the mammalian brain and eye. Prostaglandins, Leukotrienes and Essential Fatty Acids 57, 305-310 (1997). 4.Ensor, C.M.,Yang, J.Y.,Okita, R.T., et al. Cloning and sequence analysis of the cDNA for human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. The Journal of Biological Chemisty 265, 14888-14891 (1990). 5.Del Vecchio, R.P.,Maxey, K.M. and Lewis, G.S. A quantitative solid-phase enzymeimmunoassay for 13,14-dihydro-15-keto-prostaglandin F2α in plasma. Prostaglandins 43, 321-330 (1992). 6.Meyer, H.H.D.,Eisele, K. and Osaso, J. A biotin-streptavidin amplified enzyme immunoassay for 13,14-dihydro-15-keto-PGF2α. Prostaglandins 38, 375-383 (1989). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 6 months |
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