| 货号 | 515211-480Solid |
| 描述 | Prostacyclin (Prostaglandin I2; PGI2) is formed from arachidonic acid primarily by the vascular endothelium and renal cortex.1,2 It is a potent vasodilator and inhibitor of platelet aggregation.2PGI2 is non-enzymatically hydrated to 6-keto PGF1α(t½ = 2-3 minutes), and then quickly converted to the major metabolite, 2,3-dinor-6-keto PGF1α(t½ = 30 minutes).3,4,5 Prostacyclin was once thought to be a circulating hormone that regulated platelet-vasculature interactions, but the rate of secretion into circulation coupled with the short half-life indicate that prostacyclin functions locally.6 Although 6-keto PGF1α is commonly measured in plasma and urine as an estimate of prostacyclin synthesis, it should be noted that there may be more than one source of PGI2 in these samples. For instance, venipuncture may cause the release of prostacyclin which will artifactually increase the 6-keto PGF1α concentration in plasma.7 Urinary concentrations of 6-keto PGF1α are confounded by the fact that some plasma prostacyclin (~14%) is excreted into urine as 6-keto PGF1α and the remainder is of renal origin.6,7 Therefore, it is important to take these factors into account when analyzing data. |
| 别名 | 6-keto PGF1α EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moncada, S.,Gryglewski, R.,Bunting, S., et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263, 663-665 (1976). 2.Navamani, M.,Morgan, M. and Williams, R.J. Ethanol modulates N-methyl-D-aspartate-evoked arachidonic acid release from neurones. European Journal of Pharmacology 340, 27-34 (1997). 3.Samuelsson, B.,Goldyne, M.,Granström, E., et al. Prostaglandins and thromboxanes. Annual Reviews of Biochemistry 47, 997-1029 (1978). 4.Dusting, G.J.,Moncada, S. and Vane, J.R. Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid. Prostaglandins 13, 3-15 (1977). 5.Rosenkranz, B.,Fischer, C.,Reimann, I., et al. Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F1α in man. Biochimica et Biophysica Acta 619, 207-213 (1980). 6.Frolich, J.C. Measurement of eicosanoids. Prostaglandins 27, 349-369 (1984). 7.Catella, F.,Nowak, J. and Fitzgerald, G.A. Measurement of renal and non-renal eicosanoid synthesis. American Journal of Medicine 81, 23-29 (1986). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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