PF CBP1 (50 MG)
货号：
5801/50 基本售价：
14058.8 元 规格：
50 mg
产品信息
概述| 货号 | 5801/50 |
| 别名 | 5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole |
性能| 供应商 | Tocris |
| 生物活性 | Selective CBP/p300 bromodomain inhibitor (IC50 values are 125 and 363 nM, respectively). Exhibits >100-fold selectivity for CBP over BRD4. Also exhibits selectivity over a panel of other bromodomains. Reduces LPS-induced IL-1β,IL-6andIFN-β expression in macrophages in vitro. Also downregulates RGS4 expression in primary cortical neurons in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 488.62 |
| 分子式 | C29H36N4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Chekleret al (2015) Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 22 1588. PMID: 26670081. |
