AMG PERK 44 (50 MG)
货号：
5517/50 基本售价：
14058.8 元 规格：
50 mg
产品信息
概述| 货号 | 5517/50 |
| 别名 | 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective PERK inhibitor (IC50 = 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 561.07 |
| 分子式 | C34H28N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Smithet al (2015) Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J.Med.Chem. 58 1426. PMID: 25587754. |
