| 货号 | 5661/50 |
| 别名 | 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-ch |
| 供应商 | Tocris |
| 生物活性 | Potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 620.52 |
| 分子式 | C33H30ClN3O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Liet al (2016) Systemic inhibition of CREB is well-tolerated in vivo. Sci.Rep. 6 34513. PMID: 27694829. Xieet al (2015) Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity J.Med.Chem. 58 5075. PMID: 26023867. |