HMB-Val-Ser-Leu-VE
货号：
10007713-25mg 基本售价：
13972.0 元 规格：
25 mg
产品信息
概述| 货号 | 10007713-25mg |
| 描述 | The 20S proteasome is a 700 kDa, multi-subunit cylinder-shaped protein that functions as the central protease within the ubiquitin-proteasome pathway utilized by cells for the regulated degradation of proteins.1,2 HMB-val-ser-leu-VE is a tripeptide bearing a C-terminal vinyl ester which acts as a potent, selective inhibitor of the trypsin-like activity of the 20S proteasome. It inhibits the tryptic-like, chymotryptic-like, and post acidic activities of the purified 20S proteasome with IC50 values of 0.33 µM, >10 µM, and >10 µM, respectively.3 HMB-val-ser-leu-VE is cell permeable and stable (t½ ~6 hours) in in vitroassays. |
性能| 供应商 | Cayman |
| 应用文献 |
1.DeMartino, G.N., and Slaughter, C.A. The proteasome, a novel protease regulated by multiple mechanisms. The Journal of Biological Chemisty 274(32), 22123-22126 (1999).
2.Ciechanover, A. The ubiquitin-proteasome proteolytic pathway. Cell 79, 13-21 (1994).
3.Marastoni, M.,Baldisserotto, A.,Cellini, S., et al. Peptidyl vinyl ester derivatives: New class of selective inhibitors of proteasome trypsin-like activity. Journal of Medicinal Chemistry 48, 5038-5042 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 505.6 |
| 分子式 | C26H39N3O7 |
| CAS号 | 862891-04-1 |
| 稳定性 | ≥ 2 years |
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