Platensimycin
货号：
15507-1mg 基本售价：
13958.0 元 规格：
1 mg
产品信息
概述| 货号 | 15507-1mg |
| 描述 | Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM).1 It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureusandE. coli enzymes, respectively).1 By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance.2 PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.3 |
| 别名 | PTM; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, J.,Soisson, S.M.,Young, K., et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441(7091), 358-361 (2006).
2.Allahverdiyev, A.M.,Bagirova, M.,Abamor, E.S., et al. The use of platensimycin and platencin to fight antibiotic resistance. Infect.Drug Resist. 6, 99-114 (2013).
3.Wu, M.,Singh, S.B.,Wang, J., et al. Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proceedings of the National Academy of Sciences of the United States of America 108(13), 5378-5383 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 442 |
| 分子式 | C24H27NO7 |
| CAS号 | 835876-32-9 |
| 稳定性 | ≥ 2 years |
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